MeFi Projects

The second major version of semi-automated genome annotation software Segway is now available! It now runs on any Linux system, no longer needing a fancy compute cluster with Grid Engine or LSF. Now you can also install it and all its dependencies with a single Bioconda command! conda install -c bioconda segway. Includes fancy new modeling methods like mixtures of Gaussians. Turns out a single Gaussian isn't the best distribution for genomic signal data. Who knew? Previously.
posted by grouse on Jun 9, 2017 - 0 comments

The free Segway software package contains a novel method for analyzing multiple tracks of functional genomics data. Our method uses a dynamic Bayesian network (DBN) model, which enables it to analyze the entire genome at 1-bp resolution even in the face of heterogeneous patterns of missing data. This method is the first application of DBN techniques to genome-scale data and the first genomic segmentation method designed for use with the maximum resolution data available from ChIP-seq experiments without downsampling. Our software has extensive documentation and was designed from the outset with external users in mind. Researchers at other universities and institutes have already installed and used Segway for their own projects.
posted by grouse on Mar 19, 2012 - 3 comments