Umap and Bismap: quantifying genome and methylome mappability
December 20, 2016 4:14 PM Subscribe
Umap and Bismap: quantifying genome and methylome mappability
Many biological experiments use DNA sequencing as a readout. We can often map the sequenced DNA back to a specific region of the genome. Sometimes, however, we can't. Genomic data is less reliable in those regions. My lab has developed software that makes it easy to identify these regions. We also developed a new method that lets us find those regions in the context of bisulfite sequencing, a technique used to determine where DNA is chemically modified.
Preprint describing our method in more detail: "Umap and Bismap: quantifying genome and methylome mappability"
Many biological experiments use DNA sequencing as a readout. We can often map the sequenced DNA back to a specific region of the genome. Sometimes, however, we can't. Genomic data is less reliable in those regions. My lab has developed software that makes it easy to identify these regions. We also developed a new method that lets us find those regions in the context of bisulfite sequencing, a technique used to determine where DNA is chemically modified.
Preprint describing our method in more detail: "Umap and Bismap: quantifying genome and methylome mappability"
Role: principal investigator
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